A single-stranded RNA virus that infects the family of bacteria that includes E. Why was it sequenced? This was the first genome to be completely sequenced. How many bases? A bacteriophage virus that attacks bacteria containing a single circle of DNA. This was the first DNA-based genome to be sequenced. Who sequenced it? A non-moving rod-shaped bacterium that causes meningitis. This was the first bacteria to be sequenced. A heat-loving, methane-producing, single-celled organism.
This was the first archaeon to be sequenced. A species of yeast used in winemaking, baking and brewing. This was the first fungi to be sequenced. A free-living, transparent worm about 1 mm in length that lives in the soil. This was the first animal to be sequenced. A small flowering plant widely used as a model organism in plant biology.
This was the first plant to have its genome sequenced. A small insect commonly found near ripening fruit. This is a widely used model organism in scientific research that has been studied for many years. Understanding the human genome will help us to improve human health. Over 95 per cent of the mouse genome is similar to our own, so studying it is really useful for discovering more about human health and disease.
It is a flying insect which feeds on the blood of animals. Further source data for Fig. There are no restrictions on use. Source data are provided with this paper.
Claussnitzer, M. A brief history of human disease genetics. Nature , — Hiller, M. Cell Rep. Wasser, S. Science , 84—87 Wright, B. Development of a SNP-based assay for measuring genetic diversity in the Tasmanian devil insurance population. BMC Genomics 16 , Lappalainen, T. Genomic analysis in the age of human genome sequencing. Cell , 70—84 Kircher, M. A general framework for estimating the relative pathogenicity of human genetic variants.
Lindblad-Toh, K. A high-resolution map of human evolutionary constraint using 29 mammals. Finucane, H. Partitioning heritability by functional annotation using genome-wide association summary statistics. Ryder, O. Viable cell culture banking for biodiversity characterization and conservation. PubMed Google Scholar. Weisenfeld, N. Comprehensive variation discovery in single human genomes. Putnam, N. Chromosome-scale shotgun assembly using an in vitro method for long-range linkage.
Genome Res. Kim, J. Reconstruction and evolutionary history of eutherian chromosomes. Natl Acad. USA , E—E Lek, M. Analysis of protein-coding genetic variation in 60, humans. Balasubramanian, S. Using ALoFT to determine the impact of putative loss-of-function variants in protein-coding genes. Meadows, J. Dissecting evolution and disease using comparative vertebrate genomics.
Cooper, G. Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data. Baiz, M.
X-linked signature of reproductive isolation in humans is mirrored in a howler monkey hybrid zone. Dobzhansky, T. Genetics and the Origin of Species Columbia Univ. Press, Abegglen, L. Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans.
CAS Google Scholar. Casewell, N. Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals. USA , — Beichman, A. Aquatic adaptation and depleted diversity: a deep dive into the genomes of the sea otter and giant otter.
Damas, J. Xue, Y. Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding. Science , — Ceballos, F. Runs of homozygosity: windows into population history and trait architecture. Spielman, D. Most species are not driven to extinction before genetic factors impact them. Vinson, J. Assembly of polymorphic genomes: algorithms and application to Ciona savignyi.
MacManes, M. The social brain: transcriptome assembly and characterization of the hippocampus from a social subterranean rodent, the colonial tuco-tuco Ctenomys sociabilis. Jones, K. Ecology 90 , Google Scholar. Cardillo, M. Biological determinants of extinction risk: why are smaller species less vulnerable? Natesh, M. Empowering conservation practice with efficient and economical genotyping from poor quality samples. Methods Ecol. Lowry, D. Breaking RAD: an evaluation of the utility of restriction site-associated DNA sequencing for genome scans of adaptation.
Shapiro, B. Pathways to de-extinction: how close can we get to resurrection of an extinct species? Benazzo, A. Survival and divergence in a small group: the extraordinary genomic history of the endangered Apennine brown bear stragglers. Saremi, N. Puma genomes from North and South America provide insights into the genomic consequences of inbreeding. Armstrong, J. Progressive Cactus is a multiple-genome aligner for the thousand-genome era.
Haeussler, M. The UCSC genome browser database: update. Nucleic Acids Res. Rands, C. PLoS Genet. An integrated encyclopedia of DNA elements in the human genome. Nature , 57—74 ADS Google Scholar. GTEx Consortium. Genetic effects on gene expression across human tissues. PubMed Central Google Scholar. Regev, A. The human cell atlas.
Lewin, H. Earth BioGenome project: sequencing life for the future of life. Koepfli, K. The Genome 10K project: a way forward. Teeling, E. Bat biology, genomes, and the Bat1K project: to generate chromosome-level genomes for all living bat species. Feng, S. Dense sampling of bird diversity increases power of comparative genomics. Kumar, S. TimeTree: a resource for timelines, timetrees, and divergence times. Wilson, D. Vlieghe, D. BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs.
Bioinformatics 31 , — A near-chromosome-scale genome assembly of the gemsbok Oryx gazella : an iconic antelope of the Kalahari desert. Gigascience 8 , giy McKenna, A. The genome analysis toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data.
DePristo, M. A framework for variation discovery and genotyping using next-generation DNA sequencing data. Li, H. Bioinformatics 25 , — Fast and accurate short read alignment with Burrows—Wheeler transform. Benaglia, T. R Core Team. Paten, B. Cactus: algorithms for genome multiple sequence alignment. Ondov, B. Mash: fast genome and metagenome distance estimation using MinHash. Genome Biol. Smit, A. RepeatMasker Open Hubisz, M.
Benjamini, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. B 57 , — Benson, D. Nguyen, N. Comparative assembly hubs: web-accessible browsers for comparative genomics.
Bioinformatics 30 , — Karczewski, K. The mutational constraint spectrum quantified from variation in , humans. Pinheiro, E. Effect of fasting on carbohydrate metabolism in frugivorous bats Artibeus lituratus and Artibeus jamaicensis.
B Biochem. Gordon, L. Amorphous intergranular phases control the properties of rodent tooth enamel. Hindle, A.
Intrinsic circannual regulation of brown adipose tissue form and function in tune with hibernation. Stanford, K. Try one of our science activities for quick, anytime science explorations. The perfect thing to liven up a rainy day, school vacation, or moment of boredom. Menu Science Projects. Project Guides. View Site Map. Science Projects. Grade Levels. Physical Science.
Earth and Environmental Science. Behavioral and Social Science. Which Animals Have Genome Projects? Note: A public database needed to do this project is no longer functional. We are working to develop a new project on this topic. Share your story with Science Buddies! Yes, I Did This Project! Please log in or create a free account to let us know how things went.
Science Buddies Staff. Accessed 12 Nov. Introduction All living things come with a set of instructions stored in their DNA, short for deoxyribonucleic acid. Retrieved June 6, Visit the Understanding Genetics: Human Health and the Genome online exhibit at the Tech Museum of Innovation to get an introduction to some model organisms who have had their genomes sequenced, and see how similar they are to humans: The Tech, How are genomes sequenced?
At the GEEE! The GEEE!
0コメント